A Genome-Wide Association Meta-Analysis of Attention-Deficit/Hyperactivity Disorder Symptoms in Population-Based Pediatric Cohorts.
نویسندگان
چکیده
OBJECTIVE The aims of this study were to elucidate the influence of common genetic variants on childhood attention-deficit/hyperactivity disorder (ADHD) symptoms, to identify genetic variants that explain its high heritability, and to investigate the genetic overlap of ADHD symptom scores with ADHD diagnosis. METHOD Within the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, genome-wide single nucleotide polymorphisms (SNPs) and ADHD symptom scores were available for 17,666 children (<13 years of age) from nine population-based cohorts. SNP-based heritability was estimated in data from the three largest cohorts. Meta-analysis based on genome-wide association (GWA) analyses with SNPs was followed by gene-based association tests, and the overlap in results with a meta-analysis in the Psychiatric Genomics Consortium (PGC) case-control ADHD study was investigated. RESULTS SNP-based heritability ranged from 5% to 34%, indicating that variation in common genetic variants influences ADHD symptom scores. The meta-analysis did not detect genome-wide significant SNPs, but three genes, lying close to each other with SNPs in high linkage disequilibrium (LD), showed a gene-wide significant association (p values between 1.46 × 10(-6) and 2.66 × 10(-6)). One gene, WASL, is involved in neuronal development. Both SNP- and gene-based analyses indicated overlap with the PGC meta-analysis results with the genetic correlation estimated at 0.96. CONCLUSION The SNP-based heritability for ADHD symptom scores indicates a polygenic architecture, and genes involved in neurite outgrowth are possibly involved. Continuous and dichotomous measures of ADHD appear to assess a genetically common phenotype. A next step is to combine data from population-based and case-control cohorts in genetic association studies to increase sample size and to improve statistical power for identifying genetic variants.
منابع مشابه
Predicting of Empathy Based on The Components of Executive Functions in Children with Attention Deficit / Hyperactivity Disorder Symptoms
The aim of the present study was to predict empathy based on the Componentchr('39')s executive functions in children with attention-deficit / hyperactivity disorder symptoms. The method of this study was descriptive and correlation. The statistical population included elementary school male students (ages 8 to 12 years) with attention-deficit/hyperactivity disorder symptoms in Tabriz in the aca...
متن کاملPredicting Cognitive Emotion Regulation and Academic Achievement Based on Symptoms of Attention Deficit / Hyperactivity Disorder
Objective: The purpose of this study was to predict cognitive emotion regulation and academic achievement based on symptoms of Attention-Deficit/ Hyperactivity Disorder. Method: The present study is a correlational design. The study population consisted of students at the University of Bojnord in the academic year 2017-18. Of these students, 190 were selected by convenience sampling. Adult sel...
متن کاملComparison of effectiveness of Attentive Behavior Self- Regulation Interventions with Motivational Behavior Self-Regulation Training on Attention Deficit / Hyperactivity Disorder (ADHD)
Objective: One of the most common childhood disorders is Attention Deficit Hyperactivity Disorder, which can be caused by a lack of self-regulation. Therefore, the present study aimed to compare the effectiveness of self-regulatory behavioral interventions with self-regulatory motivational behavior on reducing the symptoms of attention deficit / hyperactivity disorder in elementary school stude...
متن کاملThe effectiveness of Dialectical Behavior Therapy on Reducing of Symptoms of Attention Deficit / Hyperactivity and Suicidal Ideation in Symptoms of Attention Deficit / Hyperactivity Disorder Adolescents
Background : Attention Deficit Hyperactivity Disorder means behavioral disorders that begin in childhood and continue into adolescence and even middle age if appropriate therapies are not used. This study aimed to evaluate the effectiveness of dialectical behavior therapy on reducing the symptoms of attention-deficit / hyperactivity disorder and suicidal ideation in adolescents with attention-d...
متن کاملEffectiveness of Neurofeedback Treatment on Adult ADHD: A Meta-Analysis
Objective: The aim of this meta-analysis was to determine the effectiveness of neurofeedback treatments in adults with Attention Deficit/ Hyperactivity Disorder (ADHD). Methods: A total of 9 studies were selected, and meta-analysis was done on them. The data were gathered from the following databases: PubMed, ScienceDirect, Springer, SID based on methodological conditions, topic and research d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of the American Academy of Child and Adolescent Psychiatry
دوره 55 10 شماره
صفحات -
تاریخ انتشار 2016